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G-protein : IP(Ca++) signaling pathway

G-protein : 신호전달 메커니즘
- cAMP path
- IP path



Inositol phospholipid signaling pathway
Receptor – G-protein (Gq) – PLC-β
PIP2 --------- IP3 + diacylglycerol
             PLC-β

IP3 / DAG pathway
IP3
IP3-gated Ca2+-release channel (ER)
DAG pathway
Serine/threonine protein kinase (PKC) 활성화; Ca2+ 의존성 (세포질세포막)
Ca2+, DAG, phosphatidylserine
Bioactive molecules에 의한 유사반응
IP3 / Ca2+ ionophore, DAG / phorbol ester (PKC와 직접결합 활성화)