Cell ¡í ¼¼Æ÷°ñ°Ý ¡í ECM
¼¼Æ÷ - Integrins
¼¼Æ÷°ñ°Ý, ECM
- ÁõÁ¡(´Ü¼ø)´Ù´ç·ù , º¹ÇÕ´Ù´ç·ù
- ¼¼Æ÷´Â Fiber µ¢¾î¸®´Ù , ¼¼Æ÷´Â Äݶó°Õ µ¢¾î¸®´Ù
- Äݶó°Õ Collagen , Äݶó°Õ Á¶¼º ¹× ÇÕ¼º°úÁ¤
- ¿¤¶ó½ºÆ¾ elastin, Proteoglycan
- Fibronectin, Laminins
- Integrins, Cadherins
1. integral, transmembrane proteins of PM
2. link the ECM with cytoskeleton thru PM protein
a. external domain of protein has binding site for ECM
-binding site for fibronectin, -binding site for laminin
b. internal domain of protein has binding site for cytoskeleton
-binding site for talin
-green = microfilament
-purple = antibody for integrin
-vinculin binds talin
-vinculin also binds microfilaments
-so, ECM can be connected to microfilaments!
3. structure of Integrins
a. two transmembrane polypeptides
b. noncovalent association
c. complex produces the binding sites
-isolated monomers are inactive
d. multiple types of alpha and beta subunits
-get many different heterodimers
-different heterodimers have different functions
-eg: heterodimers with beta-1 subunit found all cells
-used to connect PM to ECM
-eg: heterodimers with beta-2 subunit found
only on white blood cells
-used in cell-cell recognition