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Cell ¡í ¼¼Æ÷°ñ°Ý ¡í ECM ¼¼Æ÷ - Integrins ¼¼Æ÷°ñ°Ý, ECM - ÁõÁ¡(´Ü¼ø)´Ù´ç·ù , º¹ÇÕ´Ù´ç·ù - ¼¼Æ÷´Â Fiber µ¢¾î¸®´Ù , ¼¼Æ÷´Â Äݶó°Õ µ¢¾î¸®´Ù - Äݶó°Õ Collagen , Äݶó°Õ Á¶¼º ¹× ÇÕ¼º°úÁ¤ - ¿¤¶ó½ºÆ¾ elastin, Proteoglycan - Fibronectin, Laminins - Integrins, Cadherins 1. integral, transmembrane proteins of PM 2. link the ECM with cytoskeleton thru PM protein a. external domain of protein has binding site for ECM -binding site for fibronectin, -binding site for laminin b. internal domain of protein has binding site for cytoskeleton -binding site for talin -green = microfilament -purple = antibody for integrin -vinculin binds talin -vinculin also binds microfilaments -so, ECM can be connected to microfilaments! 3. structure of Integrins a. two transmembrane polypeptides b. noncovalent association c. complex produces the binding sites -isolated monomers are inactive d. multiple types of alpha and beta subunits -get many different heterodimers -different heterodimers have different functions -eg: heterodimers with beta-1 subunit found all cells -used to connect PM to ECM -eg: heterodimers with beta-2 subunit found only on white blood cells -used in cell-cell recognition |
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