Integrins

Cell ≫ 세포골격 ≫ ECM

세포 - Integrins

세포골격, ECM
- 증점(단순)다당류 , 복합다당류
- 세포는 Fiber 덩어리다 , 세포는 콜라겐 덩어리다
- 콜라겐 Collagen ,  콜라겐 조성 및 합성과정
- 엘라스틴 elastin,  Proteoglycan
- Fibronectin,  Laminins
- Integrins,  Cadherins
    
           1. integral, transmembrane proteins of PM
           2. link the ECM with cytoskeleton thru PM protein
                a. external domain of protein has binding site for ECM
                        -binding site for fibronectin,  -binding site for laminin
                b. internal domain of protein has binding site for cytoskeleton
                        -binding site for talin
                               -green = microfilament
                               -purple = antibody for integrin
                        -vinculin binds talin
                        -vinculin also binds microfilaments
                        -so, ECM can be connected to microfilaments!
          3. structure of Integrins  
                a. two transmembrane polypeptides
                b. noncovalent association
                c. complex produces the binding sites
                     -isolated monomers are inactive
                d. multiple types of alpha and beta subunits
                        -get many different heterodimers
                        -different heterodimers have different functions
                                 -eg: heterodimers with beta-1 subunit found all cells
                                               -used to connect PM to ECM
                                -eg: heterodimers with beta-2 subunit found
                                         only on white blood cells
                                              -used in cell-cell recognition  

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