µ¶°ú¾à : drug design(ÇüÅÂ,¿ëÇصµ)
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drug design(ÇüÅÂ,¿ëÇصµ)
drug design : µ¶°ú¾à
- ½Å¾à °³¹ß È®·ü
- GPCR ¿ªÇÒ : ½Å¾à °³¹ßÀÇ µ¹Æı¸ : ¾à¹° ÀÛ¿ëÀÇ Àý¹Ý
- ¾àÀÇ ºÐÀÚÇüÅ QSAR
- °í¾Æ GPCR
- ºÐÀÚ·® :
- ¿ëÇصµ :
1. Natural Products: MW ~400-1000
Structurally highly diverse, Often biologically active
Optimization process is time consuming, High manufacturing costs
2. Synthetic compounds collections: M.W ~300-350.
Drug-like, Structural diversity is limited
Optimization process straightforward, Low manufacturing costs
3. Peptoids, peptides and peptidomimetics derived from a target protein : M.W >600
Fast assembly through linear assembly of similar¡¤building blocks
Limited,¡°rather flexible¡± diversity.
Usually not ¡°drug-like¡±, Optimization process often long and tedious
4. Small-molecular-weight compound libraries from combinatorial and parallel chemistry: Molecular weight <600.
Fast and convergent assembly using reactive building blocks
Limited chemica1and structural diversity
¡°Drug-like¡±, Fast optimization process, Low manufactoring costs
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½Ä¿å mechanism
- Food Pleasure
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