cadherins
Cell ¡í ¼¼Æ÷°ñ°Ý ¡í ECM
¼¼Æ÷ - cadherins
¼¼Æ÷°ñ°Ý, ECM
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- ¼¼Æ÷´Â Fiber µ¢¾î¸®´Ù , ¼¼Æ÷´Â Äݶó°Õ µ¢¾î¸®´Ù
- Äݶó°Õ Collagen , Äݶó°Õ Á¶¼º ¹× ÇÕ¼º°úÁ¤
- ¿¤¶ó½ºÆ¾ elastin, Proteoglycan
- Fibronectin, Laminins
- Integrins, Cadherins
humans/114 genes for cadherins
a. adhesive glycoproteins found on PM
b. cadherin on one cell bind to cadherin of same type on adjacent cell
c. experiments showing importance of cadherin
- make an antibody specific for cadherin
- expose cells to antibody
- antibody binds to cadherin and prevents cadherin from its binding functions
- cells don't bind to each other properly
- tissues don't develop
d. cadherins require Ca+2 for proper function
- binding domains shown in blue and green
- Ca+2 shown in red
e. function of cadherins
- hold adjacent cells together to help form tissues
- different cadherins in different tissues come from different genes
-eg: liver cadherins, -eg: heart cadherins, -eg: epithelial cadherins
- eg: placental cadherins, -eg: neural cadherins
3) N-CAM = neural cell adhesion molecule
a. special adhesive proteins for nerve cells
-20 different forms
-ONLY ONE GENE!
-like immunoglobulins, different forms
come from alternate splicings
b. experiments showing importance of N-CAM
- make an antibody specific for N-CAM
- expose embryonic nerve cells to antibody
- antibody binds to N-CAM
- nerve cells don't bind to each other properly to make neural tissue
c. structure of N-CAM
-glycoprotein
-Ca+2 independent binding
-multiple IgG like binding domains
-transmembrane protein of PM
-extracellular domains have binding sites for the extracellular domain of another N-CAM
-binds to SELF
-internal domain binds to cytoskeleton
d. function of N-CAM
-hold adjacent nerve cells together
-help develop nerve tissues
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