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G-protein : IP(Ca++) signaling pathway

G-protein : ½ÅÈ£Àü´Þ ¸ÞÄ¿´ÏÁò
- cAMP path
- IP path



Inositol phospholipid signaling pathway
Receptor – G-protein (Gq) – PLC-¥â
PIP2 --------- IP3 + diacylglycerol
             PLC-¥â

IP3 / DAG pathway
IP3
IP3-gated Ca2+-release channel (ER)
DAG pathway
Serine/threonine protein kinase (PKC) È°¼ºÈ­; Ca2+ ÀÇÁ¸¼º (¼¼Æ÷Áú¼¼Æ÷¸·)
Ca2+, DAG, phosphatidylserine
Bioactive molecules¿¡ ÀÇÇÑ À¯»ç¹ÝÀÀ
IP3 / Ca2+ ionophore, DAG / phorbol ester (PKC¿Í Á÷Á¢°áÇÕ È°¼ºÈ­)