Cell ¡í ¼¼Æ÷°ñ°Ý ¡í ECM ¡í ¹ÙÀÌ¿ÀÆú¸®¸Ó
¼¼Æ÷ - ECM Extracellular matrix, Cell junction
¼¼Æ÷°ñ°Ý, ECM
- ÁõÁ¡(´Ü¼ø)´Ù´ç·ù , º¹ÇÕ´Ù´ç·ù
- ¼¼Æ÷´Â Fiber µ¢¾î¸®´Ù , ¼¼Æ÷´Â Äݶó°Õ µ¢¾î¸®´Ù
- Äݶó°Õ Collagen , Äݶó°Õ Á¶¼º ¹× ÇÕ¼º°úÁ¤
- ¿¤¶ó½ºÆ¾ elastin, Proteoglycan
- Fibronectin, Laminins
- Integrins, Cadherins
- ´ãÀïÀ̵¢±¼ : ¾Æ¶óºñ³ë°¥¶ôź
- ¼¼±Õ(ÁøÇÙ,¿øÇÙ), °í¼¼±ÕÀÇ ¸·±¸Á¶
- glycobiology
I. Extracellular Matrix (ECM) of Animal Cells nc1a, nc1b
A. variety of forms : nc2a, nc2b
- bone, cartilege, connective tissue
B. function of ECM nc4a, nc4b
1. helps determine cell shape
2. helps determine mechanical properties of cell
3. helps determine tissue properties
4. helps in cell recognition
5. helps in cell adhesion
C. three classes of molecules form ECM
1. structural proteins : give ECM strength(collagens) and flexibility(elastins)
2. protein-polysaccharide complexes
proteoglycans = provide matrix in which the other proteins are organized
3. adhesive glycoproteins : fibronectin, laminins
D. collagens are structural proteins of ECM
E. Elastins are structural proteins of ECM
F. Proteoglycan Matrix of ECM
II. Adhesion and Cell-Cell Recognition
A. proteoglycans and the plasma membrane
1. adhesive glycoproteins found associated with PM
2. adhesive glycoproteins connect PM to ECM
3. two major types of adhesive glycoproteins
a. fibronectins, b. laminins
B. Fibronectin
C. Laminins
D. Integrins
E. What holds cells together?
1) adhesive glycoproteins : cadherins, N-CAMs