2Â÷Àü·É : Cyclic AMP(cAMP) path - from adenosine triphosphate (ATP) The cAMP Dependent Pathway is used as a signal transduction pathway for many hormones including: ADH - Promotes water retention by the kidneys (V2 Cells of Posterior Pituitary) GHRH - Stimulates the synthesis and release of GH (Somatotroph Cells of Anterior Pituitary) GHIH - Inhibits the synthesis and release of GH (Somatotroph Cells of Anterior Pituitary) CRH - Stimulates the synthesis and release of ACTH (Anterior Pituitary) ACTH - Stimulates the synthesis and release of Cortisol (zona fasiculata of adrenal cortex in kidneys) TSH - Stimulates the synthesis and release of a majority of T4 (Thyroid Gland) LH - Stimulates follicular maturation and ovulation in women; Stimulates testosterone production and spermatogenesis in men FSH - Stimulates follicular development in women; Stimulates spermatogenesis in men PTH - Increases blood calcium levels (PTH1 Receptor: Kidneys and Bone; PTH2 Receptor: Central Nervous system, Bones, Kidneys, Brain) Calcitonin - Decreases blood calcium levels (Calcitonin Receptor: Intestines, Bones, Kidneys, Brain) Glucagon - Stimulates glycogen breakdown (liver) hCG - Promotes cellular differentiation; Potentially involved in apoptosis G¥ái inhibits the production of cAMP from ATP. G¥áq/11 stimulates membrane-bound phospholipase C beta, which then cleaves PIP2 (a minor membrane phosphoinositol) into two second messengers, IP3 and diacylglycerol (DAG). |
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