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´Ü¹éÁú ¡í ¿ªÇÒ ¡í È¿¼Ò È¿¼Ò ÀúÇØÁ¦ inhibitor È¿¼ÒÀúÇØÁ¦ (inhibitor) - Æ®¸³½Å ÀúÇØÁ¦(Trypsin inhibitor) - glufosinate, ±Û·çŸ¹Î ÇÕ¼ºÈ¿¼Ò ÀúÇØ - ±Û¸®Æ÷¼¼ÀÌÆ® EPSP ÀúÇØ - ¼Ò¸£ºó»ê º¸Á¸·á ÀÛ¿ë±âÀÛ ÀúÇØÁ¦ inhibitor - Æ®¸³½Å ÀúÇØÁ¦ - ºÀ¼âÁ¦ : ÇÇÆ®»ê, ¿Á»ì»ê oxalic acid ÀÚ¿¬µ¶ : Ç׿µ¾ç¼Ò - »ýÄáÀÇ Ç׿µ¾ç¼Ò °¡¸£½Ã´Ï¾Æ įº¸Áö¾Æ´Â Àεµ µî µ¿³²¾Æ½Ã¾Æ°¡ ¿ø»êÁö´Ù. °¡¸£½Ã´Ï¾Æ įº¸Áö¾Æ ÃßÃâ¹°Àº °¡¸£½Ã´Ï¾Æ įº¸Áö¾Æ ¿¸ÅÀÇ ²®Áú¿¡¼ ¸¸µç´Ù. ²®Áú¿¡ ÀÖ´Â HCA(È÷µå·Ï½Ã½ÃÆ®¸¯»ê, hydroxycitric acid)°¡ À¯È¿¼ººÐÀ̶ó¼´Ù. ¸»¸° ²®ÁúÀÇ ÃßÃâ¹°¿¡´Â 50~60%ÀÇ HCA°¡ µé¾î ÀÖ´Ù. HCA´Â ź¼öȹ°ÀÌ Áö¹æÀ¸·Î ÇÕ¼ºµÇ´Âµ¥ ÇÊ¿äÇÑ È¿¼Ò(citrate lyase)ÀÇ ÀÛ¿ëÀ» ¸·¾Æ Áö¹æ ÃàÀûÀ» ÁÙ¿©ÁØ´Ù. ½Ä»ç 30ºÐ~1½Ã°£ Àü¿¡ ¼·ÃëÇÏ´Â °Ô ÁÁÀºµ¥ 2½Ã°£ Àü±îÁöµµ ±¦Âú´Ù. ½ÄÇ°ÀǾàÇ°¾ÈÀüó¿¡¼ Á¦½ÃÇÏ´Â ÇÏ·ç ¼·Ãë·®Àº HCA ±âÁØÀ¸·Î 750~2800mgÀÌ´Ù. ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer of apparently identical subunits. The product, acetyl-CoA, in animals serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis.[4] It is activated by insulin.[5] In plants, ATP citrate lyase generates the acetyl-CoA for cytosolically-synthesized metabolites. (Acetyl-CoA is not transported across subcellular membranes of plants.) These include: elongated fatty acids (used in seed oils, membrane phospholipids, the ceramide moiety of sphingolipids, cuticle, cutin, and suberin); flavonoids; malonic acid; acetylated phenolics, alkaloids, isoprenoids, anthocyanins, and sugars; and, mevalonate-derived isoprenoids (e.g., sesquiterpenes, sterols, brassinosteroids); malonyl and acyl-derivatives (d-amino acids, malonylated flavonoids, acylated, prenylated and malonated proteins).[3] De novo fatty acid biosynthesis in plants is plastidic, thus ATP citrate lyase is not important for this pathway. citrate + ATP + CoA ¡æ oxaloacetate + Acetyl-CoA + ADP + Pi |
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