Cell ≫ 세포골격 ≫ ECM

세포 - cadherins

세포골격, ECM
- 증점(단순)다당류 , 복합다당류
- 세포는 Fiber 덩어리다 , 세포는 콜라겐 덩어리다
- 콜라겐 Collagen ,  콜라겐 조성 및 합성과정
- 엘라스틴 elastin,  Proteoglycan
- Fibronectin,  Laminins
- Integrins,  Cadherins

humans/114 genes for cadherins

  a. adhesive glycoproteins found on PM
  b.  cadherin on one cell bind to cadherin of same type on adjacent cell
  c. experiments showing importance of cadherin
    - make an antibody specific for cadherin
    - expose cells to antibody
    - antibody binds to cadherin and prevents  cadherin from its binding functions
    - cells don't bind to each other properly
    - tissues don't develop
  d. cadherins require Ca+2 for proper function
    - binding domains shown in blue and green
    - Ca+2 shown in red
  e. function of cadherins
    - hold adjacent cells together to help   form tissues
    - different cadherins in different tissues come from   different genes
      -eg: liver cadherins, -eg: heart cadherins,      -eg: epithelial cadherins
    - eg: placental cadherins,    -eg: neural cadherins    




  3) N-CAM = neural cell adhesion molecule
     a. special adhesive proteins for nerve cells
      -20 different forms
                                -ONLY ONE GENE!
                                -like immunoglobulins, different forms
                                 come from alternate splicings
    b. experiments showing importance of N-CAM
     - make an antibody specific for N-CAM
     - expose embryonic nerve cells to antibody
     - antibody binds to N-CAM
     - nerve cells don't bind to each other properly to make neural tissue
   c. structure of N-CAM
    -glycoprotein
    -Ca+2  independent binding
    -multiple IgG like binding domains
    -transmembrane protein of PM
    -extracellular domains have binding sites  for the extracellular domain of  another N-CAM
         -binds to SELF
    -internal domain binds to cytoskeleton
   d. function of N-CAM
                              -hold adjacent nerve cells together
                              -help develop nerve tissues