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¿¤¶ó½ºÆ¾ elastin   

¼¼Æ÷°ñ°Ý, ECM
- ÁõÁ¡(´Ü¼ø)´Ù´ç·ù , º¹ÇÕ´Ù´ç·ù
- ¼¼Æ÷´Â Fiber µ¢¾î¸®´Ù ,
- Äݶó°Õ Collagen ,  Äݶó°Õ Á¶¼º ¹× ÇÕ¼º°úÁ¤
- ¿¤¶ó½ºÆ¾ elastin,  Proteoglycan

1. collagen fibers give ECM great tensile strength
               and produce strong and sometimes rigid tissues
2.  some tissues need to be highly flexible
     -eg: lung tissue,  -eg: arteries,         -eg: intestines     -eg: muscles
3.  elasticity provided by the "elastins"
4.  elastins = family of elastic fibers rich in glycine and  proline and located in the ECM
     -elastins have no hydroxylated proline
     -elastins have no hydroxylysine
     -elastins are crosslinked through   their lysine residues
5.  structure of elastins  
      -relaxed conformation
                       -polypeptide backbone has many bends due  many proline residues
                       -some crosslink through occasional lysine residues
    -stretched conformation
                      -covalent crosslinks keep the elastin fibers connected
                      -bends and twists are "pulled out"
                      -elastin fibers become more linear
   -tension removed
                      -elastin fibers snap back into their  relaxed configuration


 
 


ÆäÀ̽ººÏ       ¹æ¸í·Ï      ¼öÁ¤ 2011-09-25 / µî·Ï 2011-09-24 / Á¶È¸ : 18355 (672)



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