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Acetylcholine(Ach)Àº  ÀûÀº ¾çÀÌ ÁÖ·Î ºÐÆ÷ÇÏÁö¸¸, Ç÷·ù·® Á¶ÀýÀ̶óµçÁö, ¿îµ¿ ±â´É°ú Learning (Hippocampus)°ú °°Àº °íµµÀÇ Á¤½Å±â´É¿¡¼­ Áß¿äÇÑ ¿ªÇÒÀ» ÇÑ´Ù.(choline´Â ³úÁ¶Á÷¿¡¼­ 10¡­20 M Á¸ÀçÇÑ´Ù.)  ÀÌ AchÀº cholinergic receptor¿¡ ÀÇÇØ ÀÎÁöµÇ´Âµ¥, ¿©±â¿¡´Â Nicotinic Receptor (Ionotropic Receptor)¿Í Muscarinic Receptor (Metabotropic Receptor)ÀÇ µÎ Á¾·ù°¡ ¹àÇôÁ³´Ù.  Nicotinic Receptor´Â 2ºÐÀÚÀÇ AchÀÌ Receptor¿¡ ºÙ¾î  Receptor-Effector º¹ÇÕüÀÇ ¸ð¾çÀÌ ¹Ù²î¸é¼­ channelÀÌ ¿­¸°´Ù. ¾Õ¼­ ¹è¿î ¹Ù¿Í °°ÀÌ Na+ÀÌ µé¾î°¨¿¡ µû¶ó postsynaptic membraneÀÌ depolarizeµÈ´Ù. µû¶ó¼­, excitatory synapseÀÌ´Ù. ÇÑ °³ÀÇ ÁÖ¸Ó´Ï(vesicle)¿¡¼­ ¾à ¸¸ °³ÀÇ AchÀÌ ½ñ¾ÆÁ® ³ª¿À°í, (¾à 0.1§Â µ¿¾È) ¾à 2õ °³ÀÇ receptor°¡ ¿­¸®°í, ¾à 2¸¸ °³ÀÇ Na+°¡ µé¾î°£´Ù.
Muscarinic Receptor´Â ´À¸° °úÁ¤ (Second Messenger System)À¸·Î ³úÀÇ cholinergic synapseÀÇ 99%°¡ muscarinic synapseÀÌ´Ù. Second Messenger System (Indirect Mechanism)ÀÇ °úÁ¤À¸·Î Receptor´Â Guanine nucleotides-Protein°ú ¦ÀÌ µÇ¾î AchÀÌ receptor¿¡ ºÙÀ¸¸é, cyclic-GuanosineDiPhosphate°¡ cyclic-GuanosineTriPhosphate (c-GTP)·Î ¹Ù²ï´Ù. c-GTP´Â ¥á-G-Protein°ú ºÙ¾îÀÖ´Ù. GTP-¥áº¹ÇÕü´Â effector¿Í ¹ÝÀÀÇÒ ¼ö ÀÖ´Â ¼¼Æ÷ ³»·Î ¶³¾îÁø´Ù(G-Protein: 1994 Nobel Prize in Physiology or Medicine). Second Messenger SystemÀÌ ±×·¯ÇϵíÀÌ, AchÀº post-synapseÀÇ muscarinic receptorÀÇ ¼ºÁú¿¡ µû¶ó, excitatoryÀÎÁö inhibitoryÀÎÁö°¡ °áÁ¤µÈ´Ù.

















 


 


 


 


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