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µ¶/¾à ¡í õ¿¬µ¶, õ¿¬¾à õ¿¬¹°¿¡ ±â¿øÇÑ ¾àÀÇ °³¹ß - Drug design - ¼¼°èÀα¸ÀÇ ¾à 60%°¡ ¾à¹°Ä¡·á¸¦ ÀüÀûÀ¸·Î ½Ä¹°À¯·¡ õ¿¬¹° ¼ÒÀç¿¡ ÀÇÁ¸ - ÃÖ±Ù 10³â °³¹ßµÈ 520Á¾ÀÇ ½Å¾à Áß 39%°¡ õ¿¬¹°, ¶Ç´Â õ¿¬¹°¿¡¼ À¯·¡µÈ ¼ººÐ - Ç×±ÕÁ¦ ¹× Ç×¾ÏÁ¦ÀÇ 60-80%°¡ õ¿¬¹° ±â¿ø¹°Áú - °¡Àå ¸¹ÀÌ ÆǸŵǰí ÀÖ´Â 20Á¾ÀÇ ºñ´Ü¹é ÀǾàÇ° Áß 9Á¾ÀÌ Ãµ¿¬¹° À¯·¡ (¿¬°£ 160¾ï ´Þ·¯ ±Ô¸ð) ¾àÀÇ ¿ª»ç ½Ãü ¸ÅÀåµÈ °÷¿¡ »À¿Í ¼ö·¹±¹È Á¢½Ã²É ¾û°ÏÄûȺР¹ß°ß ±â¿øÀü 4õ³â ¾àÀÇ À̸§À» »õ°ÜµÐ Á¡ÅäÆÇÀÌ ¹ß°ß ÁÖ°ø ´Ü(Áß±¹ ÁÖ³ª¶ó Á¤Ä¡°¡ -¿ªÁÖ) : ÁÖ·ÊÆíÂù 1. ÇÕ¼ºÀÌ ¾î·Á¿î (ºÒ°¡´ÉÇÏÁø ¾ÊÀ¸³ª) ¹°Áú°ø±Þ - cardiac glycoside - reserpine - ergot alkaloid 2. Lead compound Á¦°ø (¸ðÇÙ) : less toxic and more effective ÇÑ ¹°Áú - antibiotica - morphine 3. ÇÕ¼ºÀÇ Áß°£Ã¼ °ø±Þ - taxol ±¸Á¶ ----- baccatin III (¿©·¯ ÁÖ¸ñ·ù¿¡ ´Ù·® ÇÔÀ¯)¿¡¼ ÇÕ¼º - corticosteroid------stigmasterol (Äá¿¡ ´Ù·®ÇÔÀ¯), dioscin 4. ½Å¾à(½Å±â´É¼º Á¦Ç°) °³¹ß: »õ·Î¿î ÀÛ¿ë, »õ·Î¿î ±âÀüÀÇ ¾à âÃâ 1. ¿¬±¸¿ª»ç 1) Ãʱâ : »ýü (½Ä¹°,µ¿¹°ÀÇ °ÇÁ¶¹°)¸¦ ±×´ë·Î »ç¿ë 2) 18C¸»ºÎÅÍ Ãµ¿¬¹°·ÎºÎÅÍ ¼ººÐ ºÐ¸® ½Ãµµ ¢¡ ½º¿þµ§ ¾à»ç Scheele (1770³â°æ) ꠑ Æ÷µµ - tartaric acid ꠛ ·¹¸ó - citric acid ꠛ »ç°ú - malic acid ꠛ ¿ìÀ¯ - lactic acid ꠗ ¼Òº¯ - uric acid 3) 19CÃÊ µ¶ÀÏ ¾à»ç Sertȕrner (1806³â°æ) ꠗ¾ÆÆí¡æmorphine ºÐ¸®---½Ä¹°¼ººÐ ÃßÃâ, ºÐ¸®È¿½Ã alkaloid È¿½Ã ¢¡ 1821³â alkaloid ¸íĪ by Meisoner 4) 20CÃÊ ꠑ Çë°¡¸® À¯±âÈÇÐÀÚ Pregl - ¹Ì·®¿ø¼Ò ºÐ¼®¹ý ¹ß¸í ꠗ ¼Ò·ÃÀÇ ½Ä¹°ÇÐÀÚ Tswet - Column Chromatography¹ý 5) 1950³â´ë: PC, TLC, GC, HPLC ․․․ºÐ¸®¹ý ¹ßÀü ÇöÀç : UV. IR. NMR. MS ․․․±¸Á¶¿¬±¸ X-ray Àý´ë±¸Á¶ |
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