식품안전 ≫ 방사선, GMO ≫ GMO

세라리니 : Spontaneous Tumors in Sprague-Dawley Rats

GMO
- GM 미지의 위험이 많다는 주장
- GM 생각보다 안전하다는 주장
- 몬산토 제초제 논란
- 세라리니, 암을 유발한다고요?
- 오로지 돌세네 : 세라리니 논문이 강력한 증거?
- 오로지 돌세네 : 글리포세이 때문에 한국에 34가지 질병이 급증?
- 강원대 임학태 교수
- 발암성 검증 실험이 쉽지 않다

SD(Sprague-Dawley) 미국의 Sprague-Dawley사에서 시판된 랫드에 기원을 가진 계통의 총칭으로 대표적인 랫드의 폐쇄군이다. 국내에서 랫드를 이용하는 실험에 가장 많이 쓰이며 주로 생물검정용, 영양시험용으로 사용된다. 성선자극호르몬에 감수성이 높다.
Sprague-Dawley, Inc.(USA)에서 번식되어 전세계적으로 가장널리 사용되는실험동물
- 비교적 대형으로 발육이 좋음- 번식과 발육이 좋음
- 온순하고 취급하기 쉬움
- 독성,약리,내분비,영양실험 등 각종 연구용으로 이용범위가 넓음

Spontaneous Tumors in Sprague-Dawley Rats

Sprague Dawley은 암에 잘 걸린다
발암물질을 주면 90일 이내에 대부분 암에 걸린다
https://www.wjgnet.com/2218-4333/full/v5/i4/677.htm
 

Spontaneous Tumors in Sprague-Dawley Rats and Swiss Mice
- J. D. Prejean, J. C. Peckham, A. E. Casey, D. P. Griswold ...
   DOI:  Published November 1973
A spontaneous tumor incidence of 45% was noted in 360 Sprague-Dawley rats (179 males and 181 females) and a 26% incidence was seen in 254 Swiss mice (101 males and 153 females) used as untreated control animals in an 18-month series of carcinogenesis experiments.
The percentage of female rats with tumors was almost double that of males, which difference was accounted for chiefly by the high incidence of mammary tumors in the females. The largest number of rat tumors occurred in the endocrine system, mainly the pituitary and adrenal glands, with females exhibiting a higher incidence than males. There were no liver tumors.
The largest group of mouse tumors occurred in the pulmonary system, with a higher incidence in females than in males. Urinary system tumors were observed in the males but not in the females. Tumors of the integument, reproductive organs, and the reticuloendothelial and lymphatic organs were also observed.

Spontaneous endocrine tumors in Sprague-Dawley rats
- Journal of Cancer Research and Clinical Oncology
- October 1979, Volume 95, Issue 2, pp 187–196
Spontaneous endocrine tumors were found in 81 of 100 Sprague-Dawley rats (42 males and 39 females) which survived for more than 2 years. Most of these tumors were medullary carcinomas of the thyroid, followed by tumors of the anterior pituitary gland, pheochromocytomas and cortical adenomas of the adrenal gland, and islet cell tumors of the pancreas. Multiple occurrence of these tumors was frequently observed. This study describes the morphology of these spontaneous endocrine tumors.

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