Hint | Food | ¸À°úÇâ | Diet | Health | ºÒ·®Áö½Ä | ÀÚ¿¬°úÇÐ | My Book | À¯Æ©ºê | Frims | ¿ø ·á | Á¦ Ç° | Update | Site |
¿ø·á ¡í µ¿¹°¼º ¡í ¾îÆзù »ý¼± ºñ¸°³× : TMA »ý¼± : ¾îÆзù - ¼±µµº¯È - »ý¼± ºñ¸°³× : ºñ¸°³× Á¦°Å - ¾Æ¼¼Æ¿Äݸ° Æ®¸±¸ÞÆ¿¾Æ¹Î(trimethylamine¡¤TMA)Àº Áú¼Ò(N)¿¡ ¸ÞÆ¿±â(CH3)°¡ 3°³³ª °áÇÕµÈ ¸Å¿ì µ¶Æ¯ÇÑ ÇüÅ·Π¿ì¸® ¸öÀÇ ½Å°æÀü´Þ¹°ÁúÀÎ ¾Æ¼¼Æ¿Äݸ°ÀÇ ÇÙ½ÉÀûÀÎ ±¸Á¶ÀÌ´Ù. ±×·±µ¥ TMA´Â »ý¼± ºñ¸°³»ÀÇ ÁÖ¹üÀÌ´Ù. ¼¼Æ÷¸·À» ±¸¼ºÇÏ´Â Æ÷½ºÆĵôÄݸ°, ¾Æ¼¼Æ¿Äݸ°, º£Å¸ÀÎ, Ä«¸£´Ïƾ¿¡¼ TMA°¡ ºÐÇØµÇ¾î ³ª¿À¸é »ý¼±ºñ¸°³»°¡ ³¯ ¼ö ÀÖ´Â °ÍÀÌ´Ù. ±×·±µ¥ ±×·± ÀÏÀº °ÅÀÇ ÀϾÁö ¾Ê´Â´Ù. È¿¼ÒÀÎ FMO3 (flavin-containing mono oxygenase 3)¿¡ ÀÇÇؼ ¹«ÃëÀÎ Æ®¸±¸Þƾ¾Æ¹Î¿Á»çÀ̵å(TMAO)·Î Áï½Ã ÀüȯµÇ±â ¶§¹®ÀÌ´Ù. ±×·±µ¥ À¯ÀüÀûÀ¸·Î FMO3ÀÇ À¯ÀüÀÚ°¡ °áÇÌµÈ »ç¶÷Àº »ý¼±ºñ¸°³»°¡ ³¯ ¼ö ÀÖ´Ù »ý¼±Àº TMAO°¡ ºñ±³Àû ÀúºÐÀÚ¶ó ü³» ¿°µµ¸¦ Á¶ÀýÇÏ´Â ¹°Áú·Î »ç¿ëÇÑ´Ù. ±×·¡¼ »ó´çÈ÷ °ú·®À» ºñÃàÇÏ°í ÀÖ´Â °ÍÀÌ´Ù. ±×·±µ¥ ¹°°í±â°¡ Á×À¸¸é Áï½Ã ü³» ¼¼±Õ°ú È¿¼Ò°¡ TMAO¸¦ ´Ù½Ã TMA·Î ºÐÇØÇϱ⠽ÃÀÛÇÑ´Ù. ºñ¸°³»°¡ ³ª±â ½ÃÀÛÇÏ´Â °ÍÀÌ´Ù. TMA°¡ È¿¼Ò¿¡ ÀÇÇØ µð¸ÞÆ¿¾Æ¹Î(DMA)ÀÌ µÇ¸é ¾Ï¸ð´Ï¾Æ ³¿»õÀÇ ¿øÀÎÀÌ µÈ´Ù. ·¹¸óÁóÀ̳ª, ½ÄÃÊ, Å丶Åä µî »ê(acid) ¼ººÐÀº TMA, DMA¿Í ¸¸³ª¸é ÀÌµé ºÐÀÚ°¡ ¹°¿¡ Àß ³ì°ÔÇÏ°í Èֹ߼º(volatility)À» ÇöÀúÇÏ°Ô ³·ÃçÁØ´Ù. ±×·¡¼ »ý¼±¹ÛÀ¸·Î ºüÁ®³ª¿À´Â ¾çÀÌ Àû¾îÁ® ºñ¸°³»°¡ ¾àÇØÁö´Â °ÍÀÌ´Ù.. Trimethylamine is degraded in the liver into trimethylamine-N-oxyde by FMO3 (flavin-containing mono oxygenase In the olfactory epithelium Further information: Trace amine-associated receptor The human trace amine-associated receptors are a group of six G protein-coupled receptors (i.e., TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, and TAAR9) that – with exception for TAAR1 – are expressed in the human olfactory epithelium.[31] In humans and other animals, TAARs in the olfactory epithelium function as olfactory receptors that detect volatile amine odorants, including certain pheromones;[31][32] these TAARs putatively function as a class of pheromone receptors involved in the olfactive detection of social cues.[31][32] A review of studies involving non-human animals indicated that TAARs in the olfactory epithelium can mediate attractive or aversive behavioral responses to a receptor agonist.[32] This review also noted that the behavioral response evoked by a TAAR can vary across species (e.g., TAAR5 mediates attraction to trimethylamine in mice and aversion to trimethylamine in rats).[32] In humans, hTAAR5 presumably mediates aversion to trimethylamine, which is known to act as an hTAAR5 agonist and to possess a foul, fishy odor that is aversive to humans;[32][33] however, hTAAR5 is not the only olfactory receptor that is responsible for trimethylamine olfaction in humans.[32][33] As of December 2015, hTAAR5-mediated trimethylamine aversion has not been examined in published research.[33] |
||||
|
|
|||