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»ý¼± ºñ¸°³× : TMA

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Æ®¸±¸ÞÆ¿¾Æ¹Î(trimethylamine¡¤TMA)Àº Áú¼Ò(N)¿¡ ¸ÞÆ¿±â(CH3)°¡ 3°³³ª °áÇÕµÈ ¸Å¿ì µ¶Æ¯ÇÑ ÇüÅ·Π¿ì¸® ¸öÀÇ ½Å°æÀü´Þ¹°ÁúÀÎ ¾Æ¼¼Æ¿Äݸ°ÀÇ ÇÙ½ÉÀûÀÎ ±¸Á¶ÀÌ´Ù.
±×·±µ¥ TMA´Â »ý¼± ºñ¸°³»ÀÇ ÁÖ¹üÀÌ´Ù. ¼¼Æ÷¸·À» ±¸¼ºÇÏ´Â Æ÷½ºÆĵôÄݸ°, ¾Æ¼¼Æ¿Äݸ°, º£Å¸ÀÎ, Ä«¸£´Ïƾ¿¡¼­ TMA°¡ ºÐÇØµÇ¾î ³ª¿À¸é »ý¼±ºñ¸°³»°¡ ³¯ ¼ö ÀÖ´Â °ÍÀÌ´Ù.
±×·±µ¥ ±×·± ÀÏÀº °ÅÀÇ ÀϾÁö ¾Ê´Â´Ù. È¿¼ÒÀÎ FMO3 (flavin-containing mono oxygenase 3)¿¡ ÀÇÇؼ­ ¹«ÃëÀÎ Æ®¸±¸Þƾ¾Æ¹Î¿Á»çÀ̵å(TMAO)·Î Áï½Ã ÀüȯµÇ±â ¶§¹®ÀÌ´Ù. ±×·±µ¥ À¯ÀüÀûÀ¸·Î FMO3ÀÇ À¯ÀüÀÚ°¡ °áÇÌµÈ »ç¶÷Àº »ý¼±ºñ¸°³»°¡ ³¯ ¼ö ÀÖ´Ù
»ý¼±Àº TMAO°¡ ºñ±³Àû ÀúºÐÀÚ¶ó ü³» ¿°µµ¸¦ Á¶ÀýÇÏ´Â ¹°Áú·Î »ç¿ëÇÑ´Ù. ±×·¡¼­ »ó´çÈ÷ °ú·®À» ºñÃàÇÏ°í ÀÖ´Â °ÍÀÌ´Ù. ±×·±µ¥ ¹°°í±â°¡ Á×À¸¸é Áï½Ã ü³» ¼¼±Õ°ú È¿¼Ò°¡ TMAO¸¦ ´Ù½Ã TMA·Î ºÐÇØÇϱ⠽ÃÀÛÇÑ´Ù. ºñ¸°³»°¡ ³ª±â ½ÃÀÛÇÏ´Â °ÍÀÌ´Ù. TMA°¡ È¿¼Ò¿¡ ÀÇÇØ µð¸ÞÆ¿¾Æ¹Î(DMA)ÀÌ µÇ¸é ¾Ï¸ð´Ï¾Æ ³¿»õÀÇ ¿øÀÎÀÌ µÈ´Ù.
·¹¸óÁóÀ̳ª, ½ÄÃÊ, Å丶Åä µî »ê(acid) ¼ººÐÀº TMA, DMA¿Í ¸¸³ª¸é ÀÌµé ºÐÀÚ°¡ ¹°¿¡ Àß ³ì°ÔÇÏ°í Èֹ߼º(volatility)À» ÇöÀúÇÏ°Ô ³·ÃçÁØ´Ù. ±×·¡¼­ »ý¼±¹ÛÀ¸·Î ºüÁ®³ª¿À´Â ¾çÀÌ Àû¾îÁ® ºñ¸°³»°¡ ¾àÇØÁö´Â °ÍÀÌ´Ù..

Trimethylamine is degraded in the liver into trimethylamine-N-oxyde by FMO3 (flavin-containing mono oxygenase

In the olfactory epithelium
Further information: Trace amine-associated receptor
The human trace amine-associated receptors are a group of six G protein-coupled receptors (i.e., TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, and TAAR9) that – with exception for TAAR1 – are expressed in the human olfactory epithelium.[31] In humans and other animals, TAARs in the olfactory epithelium function as olfactory receptors that detect volatile amine odorants, including certain pheromones;[31][32] these TAARs putatively function as a class of pheromone receptors involved in the olfactive detection of social cues.[31][32]
A review of studies involving non-human animals indicated that TAARs in the olfactory epithelium can mediate attractive or aversive behavioral responses to a receptor agonist.[32] This review also noted that the behavioral response evoked by a TAAR can vary across species (e.g., TAAR5 mediates attraction to trimethylamine in mice and aversion to trimethylamine in rats).[32] In humans, hTAAR5 presumably mediates aversion to trimethylamine, which is known to act as an hTAAR5 agonist and to possess a foul, fishy odor that is aversive to humans;[32][33] however, hTAAR5 is not the only olfactory receptor that is responsible for trimethylamine olfaction in humans.[32][33] As of December 2015, hTAAR5-mediated trimethylamine aversion has not been examined in published research.[33]


 

 

 




 




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